Spinach Artichoke Chicken Casserole Recipe

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There’s nothing better than taking a beloved classic and turning it into a satisfying, easy-to-make meal! If you love spinach artichoke dip, get ready to fall in love with this Spinach Artichoke Chicken Casserole. Packed with tender shredded chicken, creamy cheese, and savory artichokes, this dish is a comforting, keto-friendly dinner option that’s ready in just 30 minutes!

This casserole is the perfect way to enjoy the flavors of your favorite dip in a hearty, protein-packed meal. Plus, it’s baked with gooey mozzarella on top, making every bite pure cheesy goodness!

Let’s dive into this irresistible recipe—your taste buds (and your whole family!) will thank you.

Why You’ll Love This Recipe

• Keto-friendly & low-carb – Perfect for those following a ketogenic diet or looking for a high-protein meal.

• Quick & easy – Just 5 minutes of prep and 25 minutes in the oven!

• Creamy & cheesy – Layers of mozzarella, Parmesan, and cream cheese make this ultra-satisfying.

• Great for meal prep – Leftovers store well and taste even better the next day!

• Family-approved – Even picky eaters will love the cheesy goodness of this dish.

What Does Spinach Artichoke Chicken Casserole Taste Like?

Imagine the rich, creamy flavor of your favorite spinach artichoke dip but with tender, juicy chicken baked into every bite. The melted mozzarella on top gives it a perfect golden, bubbly finish, while the garlic and Parmesan add a depth of flavor that makes this dish completely irresistible.

It’s cheesy, garlicky, and just the right amount of savory, making it the ultimate comfort food!

Ingredients You’ll Need

Here’s everything you’ll need to make this mouthwatering spinach artichoke chicken casserole:

Main Ingredients

• 4 cups cooked chicken, shredded or chopped

• 9 oz frozen spinach, thawed and well-drained

• 14 oz artichoke hearts, chopped (plain, not marinated)

• 8 oz cream cheese, at room temperature

• 1 cup Parmesan cheese, grated

• 1 ½ cups shredded mozzarella cheese

• ⅔ cup sour cream

• ½ cup heavy cream

• ¼ cup mayonnaise (homemade or store-bought)

• 3 cloves garlic, minced

• Salt & pepper to taste

Kitchen Tools Needed

• Large mixing bowl

• 9×13-inch baking dish

• Nonstick cooking spray

• Spatula for mixing

• Oven

Ingredient Additions & Substitutions

Want to customize this dish? Here are some ways to switch it up:

 Add more protein – Try mixing in crumbled bacon or chopped cooked sausage for an extra flavor boost.

 Make it spicier – Stir in red pepper flakes or a dash of hot sauce to add some heat.

 Swap the spinach – If you’re out of frozen spinach, use fresh spinach (just sauté it briefly first) or even kale!

 Try a different cheese – Instead of mozzarella, use cheddar, gouda, or pepper jack for a different cheesy flavor.

How to Make Spinach Artichoke Chicken Casserole

Step 1: Preheat & Prep

Preheat your oven to 375°F (190°C). Lightly grease a 9×13-inch baking dish with nonstick cooking spray.

Step 2: Mix the Creamy Base

In a large mixing bowl, combine:

• Cream cheese

• Sour cream

• Heavy cream

• Mayonnaise

• Minced garlic

• Salt & pepper

Mix until smooth and well blended.

Step 3: Add the Chicken & Veggies

Add in the shredded chicken, spinach, and chopped artichokes. Sprinkle in grated Parmesan cheese and mix everything together.

Step 4: Assemble & Bake

Pour the mixture into the prepared baking dish and spread it out evenly. Sprinkle mozzarella cheese over the top.

Bake for 20 minutes at 375°F. Then, increase the temperature to 400°F and bake for an additional 5 minutes until the cheese is golden and bubbly.

Step 5: Serve & Enjoy

Let the casserole cool for a few minutes before serving. This helps the flavors meld together and makes it easier to scoop.

What to Serve with Spinach Artichoke Chicken Casserole

This dish is rich and creamy on its own, but if you’re looking for side pairings, try:

 A fresh green salad – A crisp Caesar salad or mixed greens with a light vinaigrette balances out the richness.

 Roasted or steamed veggies – Try asparagus, broccoli, or Brussels sprouts for extra nutrition.

 Keto-friendly bread – A slice of low-carb garlic bread or almond flour biscuits is perfect for scooping up all that cheesy goodness!

Tips for the Best Casserole

 Use rotisserie chicken – For the easiest prep, grab a pre-cooked rotisserie chicken and shred it up!

 Drain the spinach well – Squeeze out as much water as possible from the spinach to prevent a watery casserole.

 Let it cool before serving – This helps the casserole firm up slightly and makes serving easier.

 Double the recipe for meal prep – This freezes beautifully! Store extra portions for easy lunches and dinners.

How to Store & Reheat Leftovers

 Refrigerator: Store in an airtight container for up to 4 days.

 Reheating: Warm in the oven at 350°F for 10 minutes or microwave for 1-2 minutes until heated through.

 Freezer: Freeze in portions for up to 3 months. Thaw overnight in the fridge before reheating.

Frequently Asked Questions

Can I prepare this casserole in advance?

Yes! You can assemble the casserole and store it in the refrigerator (uncooked) for up to 24 hours before baking. When you’re ready, just pop it in the oven and bake as directed!

Is this a gluten-free recipe?

Yes! This casserole is 100% gluten-free, but be sure to double-check ingredients like mayonnaise and dairy products for any hidden gluten.

Can I swap frozen spinach for fresh spinach?

Absolutely! Simply sauté fresh spinach for a few minutes until wilted before mixing it into the casserole.

What’s the easiest way to shred chicken?

Use two forks to pull the chicken apart, or for a faster method, try using a hand mixer or stand mixer to shred it in seconds!

Can I freeze this casserole?

Yes! You can freeze the fully baked casserole for up to 3 months. Let it cool completely, wrap it tightly, and store it in an airtight container. Thaw overnight in the fridge before reheating.

How do I prevent my casserole from being watery?

Make sure to drain the spinach well by squeezing out any excess moisture. Also, pat the artichokes dry before chopping them to avoid extra liquid in the dish.

Can I make this casserole dairy-free?

Yes! Substitute dairy-free cream cheese, sour cream, and cheese alternatives to create a lactose-free version of this dish.

What protein alternatives can I use instead of chicken?

Try substituting with turkey, shredded pork, or even canned tuna for a different take on this casserole!

What are the best sides to serve with this dish?

Pair it with a fresh green salad, roasted vegetables, or keto-friendly garlic bread for a complete and delicious meal.

Can I add extra ingredients for more flavor?

Definitely! Add crispy bacon, sun-dried tomatoes, mushrooms, or even a dash of red pepper flakes for extra flavor and texture.

Final Thoughts: A Casserole You’ll Make Again & Again!

This Spinach Artichoke Chicken Casserole is pure comfort food—cheesy, creamy, and packed with flavor. It’s the perfect low-carb, high-protein meal for busy nights, meal prep, or sharing with family and friends.

Give this recipe a try and let me know how it turned out! Snap a picture and share it on Pinterest—I’d love to see your delicious creations!

More Spinach & Chicken Recipes to Try:

• Spinach Artichoke Stuffed Chicken Breast

• Spinach Feta Stuffed Chicken

• Spinach Stuffed Chicken Breast

Enjoy every cheesy, delicious bite!

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