Cheesy Cajun Chicken Twisted Pasta in Creamy Mozzarella Alfredo Sauce

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If Cheesy Cajun Chicken Twisted Pasta in Creamy Mozzarella Alfredo Sauce sounds like a mouthful — just wait until you taste it. This bold, creamy dish is the kind of comfort food that wins hearts fast. With tender Cajun-spiced chicken, perfectly al dente rotini, and a mozzarella-Parmesan Alfredo sauce that clings to every twist, it’s a flavor-packed favorite in my kitchen. Whether you’re cooking for family or just yourself, it delivers warmth, spice, and indulgence in every bite.

I’m so glad you’re here — welcome to my kitchen! Make sure to follow me on Pinterest and subscribe for more crave-worthy recipes like this one that always bring people back for seconds.

A Memory Served with Mozzarella

The very first time I made this cheesy Cajun chicken pasta, it was a chilly Sunday, and I wanted something bold to counter the gray skies. I remembered the way my aunt used to toss pasta in a creamy white sauce, always with a Southern twist — and the smell of garlic and spice instantly transported me. Cajun seasoning was her secret weapon, and today, it’s mine too.

Twisted pasta like rotini is perfect for clinging to that luscious sauce. I chose mozzarella to soften the heat and give it that melt-in-your-mouth finish. The way the cheese stretches as you swirl your fork through the noodles — it’s pure comfort in a bowl.

That night, the whole family sat around the table. We served this with buttery bread and a side of Chicken Scampi Pasta for comparison — and everyone went for seconds of the Cajun twist. The balance of spice and cream had them hooked.

Why This Recipe Is So Special

This pasta brings together everything I love in a weeknight dinner: it’s bold, it’s fast, and it’s always a hit. The Cajun spices aren’t overwhelming — they add just enough kick to keep things interesting. Combine that with tender chicken, al dente pasta, and a sauce so creamy it could be a main character, and you’ve got magic.

What makes it stand out is the mozzarella — it gives a silkiness that’s lighter than cheddar but richer than cream alone. I’ve found it even outshines classics like Bruschetta Chicken Pasta when you’re looking for something truly indulgent yet balanced.

Ingredients & Preparation

Let’s Break Down the Ingredients

Here’s what you’ll need to bring this Cajun comfort dish to life:

For the Cajun Chicken	For the Alfredo Pasta
2 large chicken breasts	12 oz rotini (or twisted pasta)
1 tbsp olive oil	2 tbsp unsalted butter
1 tbsp Cajun seasoning	3 cloves garlic, minced
1 tsp garlic powder	1 1/4 cups heavy cream
1/2 tsp smoked paprika	1 cup whole milk
1/4 tsp black pepper	1 1/2 cups shredded mozzarella
1/2 tsp salt	1/4 cup grated Parmesan
Juice of 1/2 lemon	Salt and black pepper, to taste
1 tbsp chopped parsley (optional)	2 tbsp chopped fresh parsley

 

These ingredients are pantry-friendly, and the beauty of it is you can always swap a few things based on what you have.

Tools & Simple Substitutions

You’ll need a large pot, a deep skillet, a chef’s knife, and a cutting board. A microplane grater makes your Parmesan ultra-fine, helping it melt seamlessly into the sauce.

If you don’t have rotini, fusilli or penne will work just fine. I’ve even tried it with Creamy Garlic Parmesan Chicken Twisted Pasta leftovers stirred in for an extra cheesy variation.

Don’t have Cajun seasoning? Try blending paprika, garlic powder, onion powder, cayenne, and a dash of thyme. Want a milder version? Use less seasoning or swap for Italian herbs.

 Cooking Instructions & Tips

Step-by-Step Method

Step 1: Cook the Pasta
Boil salted water and cook your rotini according to the package directions. Drain and set aside.

Step 2: Season & Cook the Chicken
Rub the chicken with olive oil, Cajun seasoning, garlic powder, paprika, pepper, salt, and lemon juice. Sear in a hot skillet for 5–6 minutes per side until golden. Remove and let rest.

Step 3: Make the Alfredo Sauce
Melt butter in a large pan. Add garlic and sauté 1–2 minutes. Pour in cream and milk, stirring gently until warm.

Step 4: Add the Cheese
Add mozzarella and Parmesan, stirring until melted and smooth. Season to taste.

Step 5: Combine Pasta & Sauce
Toss in the pasta and parsley. Stir until everything’s coated in cheesy goodness.

Step 6: Serve It Up
Plate the pasta, top with sliced chicken, and garnish with parsley.

Tips for Perfection

• Rest the chicken before slicing — it locks in the juices.

• Always salt your pasta water; it’s the only chance to season the noodles themselves.

• Use freshly shredded cheese for best melt — pre-shredded can turn grainy.

For more ideas, look at how Stuffed Chicken with Roasted Red Pepper, Spinach & Mozzarella achieves melty perfection.

 Serving, Storing & Pairing

What to Serve With It

This pasta is hearty, so pair it with something crisp and refreshing like a Lemon Arugula Pasta Salad. For a warm side, a scoop of Mediterranean Orzo with Roasted Vegetables works wonders.

Want to go full Southern comfort? Garlic bread or a wedge of cornbread turns it into a soulful feast.

Storing & Reheating

This pasta stores beautifully. Keep leftovers in an airtight container in the fridge for up to 3 days.

To reheat:

• Microwave with a splash of milk to keep it creamy.

• Or reheat gently on the stovetop over low heat, stirring frequently.

Avoid freezing — the sauce can separate, and texture may suffer.

FAQ Section

Can I use a different pasta shape?
Absolutely. Penne, fusilli, or cavatappi all work great — just avoid thin noodles that won’t hold the sauce.

What if I don’t have heavy cream?
Substitute with half-and-half, though the result will be slightly less rich.

Is this dish spicy?
It has a mild kick. You can adjust the Cajun seasoning or add chili flakes for extra heat.

Can I make this vegetarian?
Sure! Skip the chicken and try sautéed mushrooms or roasted cauliflower instead.

How long will leftovers last?
Up to 3 days in the fridge — reheat gently for best results.

Conclusion

This Cheesy Cajun Chicken Twisted Pasta with Creamy Mozzarella Alfredo Sauce is bold, satisfying, and guaranteed to impress. Whether you’re serving a crowd or indulging solo, it delivers flavor and comfort in every bite.

For more cozy dinners, check out my Golden Crispy Chicken with Parmesan Mushroom Sauce and the zesty Red Snapper with Creamy Creole Sauce. Both pair perfectly with this pasta or stand strong on their own.

If you loved this recipe, rate it, leave a comment below, and pin it to your Pinterest board at Recipes by Sylvia on Pinterest. I’d love to hear how yours turned out!

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